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Gabapentin is used as an adjunctive therapy for the treatment of partial seizures and the management of postherpetic neuralgia (nerve pain caused by herpes zoster). It is approved for the treatment of diabetic peripheral neuropathy and postherpetic neuralgia. Gabapentin enacarbil, a prodrug of gabapentin, is approved for the treatment of moderate to severe primary restless legs syndrome. This can also be used "off-label" to help reduce hot flashes in menopausal women.

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The dosage of gabapentin depends on the specific condition being treated. It is usually started at a low dose, which is then gradually increased based on individual response and tolerability. The typical dose range for adults is 900-3600 mg per day, divided into three dose